Farnesoid X receptor agonism prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease
B. A. Jones, K. Myakala, M. Guha, S. Davidson, S. Adapa, I. Lopez Santiago, I. Schaffer, Y. Yue, J. Allegood, L. A. Cowart, X. X. Wang, A. Z. Rosenberg, M. Levi
This study shows FXR agonism reduces kidney NETosis in male mice by inhibiting S1P signaling, but not in females.
bioRxiv · Mar 1, 2023Pharmacology & Toxicology