Y. Yue

DeCOIL optimizes degenerate codon libraries for ML-assisted protein engineering to generate diverse and high-fitness protein variants.

This study shows FXR agonism reduces kidney NETosis in male mice by inhibiting S1P signaling, but not in females.

This study redefines hematopoietic progenitor cells and reformulates the hematopoiesis hierarchy using a transcriptional atlas, identifying key transcription factors and distinct lineage commitment processes.

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

This study demonstrates that TRPV1-mediated sonogenetics can safely modulate motor cortex activity in mice, inducing behavioral changes without significant tissue damage.

This paper presents a chromosome-level genome assembly of Euphorbia peplus, identifies a gene cluster for ingenol mebutate biosynthesis, and explains its small genome size through restricted Ty3 transposon expansion.

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study shows a kinesin-1 variant causes microtubule damage in cells, leading to breakage and fragmentation, suggesting evolutionary pressure against such variants.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study identifies PPE36 as a Mycobacterium tuberculosis protein that modulates host inflammation by promoting Smurf1-mediated MyD88 degradation, enhancing bacterial survival.

This paper develops a stable transformation technique for the hornwort Anthoceros agrestis using Agrobacterium, enabling genetic studies of molecular mechanisms in land plants.

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

The paper withdraws its manuscript due to the need for further experiments to validate conclusions.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

This study shows that KIF7, an atypical kinesin, is autoinhibited to prevent microtubule binding and microtubule dynamics alteration in cells.

The paper shows that autoinhibition of kinesin-1 is crucial for dendrite-specific Golgi outpost localization, preventing their mislocalization to axons.