M. Levi

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments.

stormTB provides a web-based mPBPK model for simulating anti-TB drug treatments in mice, enabling pharmacokinetic comparisons and supporting 11 drugs.

Farnesoid X receptor agonism prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

This study shows FXR agonism reduces kidney NETosis in male mice by inhibiting S1P signaling, but not in females.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice

This study shows that Esm-1 reduces albuminuria and podocyte injury in diabetic mice, possibly through inhibiting interferon signaling.

A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

Diffuse ions coordinate dynamics in a ribonucleoprotein assembly

The paper presents a model to quantify the impact of diffuse ions on RNP assembly dynamics, showing their role in controlling tRNA movement during translation.

Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.

This study shows that adenovirus-mediated ACE2 expression in mice causes obesity-specific morbidity, complicating research on SARS-CoV-2 pathogenesis in different nutritional states.

Simultaneous Morphology, Motility and Fragmentation Analysis of Live Individual Sperm Cells for Male Fertility Evaluation

The paper introduces a stain-free method for analyzing sperm morphology, motility, and DNA fragmentation using interferometric imaging and deep learning, improving male fertility evaluation consistency.

PodoCount: A robust, fully automated whole-slide podocyte quantification tool

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

TAZ/TEAD complex regulates TGF-β1-mediated fibrosis in iPSC-derived renal organoids

This study shows that INT-767 prevents fibrosis in iPSC-derived renal organoids by modulating the TEAD4/TAZ pathway.

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

An in situ atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

Dissecting the energetics of subunit rotation in the ribosome

This study evaluates experimentally-accessible measures to identify the free-energy barrier and transition state ensemble in ribosome subunit rotation using simulated rotation events.

Using SMOG 2 to simulate complex biomolecular assemblies

The paper introduces SMOG 2, a software package for designing and simulating structure-based biomolecular models using XML templates and PDB structures.