NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni
M. Suresh Kumar Meena Kumari, P. Liu, K. Jump, Y. Morales, E. A. Miller, I. Shecter, M. J. Stadecker, P. Kalantari
This study identifies NLRP3 and AIM2 inflammasomes as key drivers of pathogenic Th17 responses in Schistosoma mansoni infection, showing their role in promoting inflammation and their counteraction by the IFN-I pathway.
bioRxiv · Mar 11, 2024 · PreprintImmunology