Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability
M. T. Patterson, Y. Xu, H. Hillman, V. Osinski, P. R. Schrank, A. E. Kennedy, A. Zhu, S. Tollison, S. Shekhar, I. Stromnes, I. Tassi, D. Wu, B. Binstadt, J. W. Williams
This study shows that a Trem2 agonist increases plaque macrophage survival and proliferation while improving plaque stability by enhancing collagen deposition and reducing necrotic core size.
bioRxiv · Sep 21, 2023Immunology