J. W. Williams

This study shows that a Trem2 agonist increases plaque macrophage survival and proliferation while improving plaque stability by enhancing collagen deposition and reducing necrotic core size.

This study shows that bariatric surgery reduces MASH through TREM2-expressing hepatic macrophages, independent of weight loss.

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.

This study identifies tumor-specific CD4 T cells as regulators of monocyte differentiation into antitumor macrophages in pancreatic ductal adenocarcinoma, showing their role in suppressing tumor growth.

This study shows that Ffar4 loss worsens cardiac inflammation and remodeling in male HFpEF-MetS mice by altering oxylipin balance.

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

The paper estimates tree biomass, stem density, and basal area in the upper Midwestern US at Euro-American settlement using PLS data and statistical smoothing.