Author

Iain C Sutcliffe

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Genetics· 1

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Organism:bacteria (other)· 1 Approach:experimental assay· 1

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David A Widdick· 1 shared Govind Chandra· 1 shared John Tyson Munnoch· 1 shared Matthew I Hutchings· 1 shared Tracy Palmer· 1 shared

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2016-2016 · peak 1/yr

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1 shared paperGenetics

David A Widdick

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GeneticsScientific ReportsPeer-reviewedJul 12, 2016

Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene

John Tyson Munnoch, David A Widdick, Govind Chandra…·Matthew I Hutchings

The paper shows that using cosmid libraries for genetic manipulation in Streptomyces coelicolor can cause unintended genetic instability and developmental defects unrelated to the targeted gene.

DOI 10.1038/srep29495

bacteria (other)experimental assay

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