Author

Isaac Lian

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Keira E. MahoneyiD· 3 shared Ryan J. CheniD· 3 shared Stacy Alyse MalakeriD· 3 shared Vincent Hung-Shu ChangiD· 3 shared Gordon W. LaurieiD· 2 shared Jeff Romano· 2 shared Niclas G. KarlssoniD· 2 shared Tor Paaske UtheimiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Keira E. MahoneyORCID

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3 papers

Recent·Most cited

Site-specific O-glycans influence lacritin structure and multimerization in tears

Vincent Hung-Shu Chang, Ryan J. Chen, Isaac Lian, Madilynn Hamilton, Keira E. Mahoney, Jeff Romano, Gordon W. Laurie, Stacy Alyse Malaker

This study investigates how site-specific O-glycans on lacritin influence its structure and multimerization, revealing their role in conformational flexibility and crosslinking residue positioning.

Protein Science · Oct 1, 2026Peer-reviewedBiophysics

Mapping galectin-3 ligands in tear fluid establishes spliceoform-dependent lacritin binding

Vincent Hung-Shu Chang, Isaac Lian, Keira E. Mahoney, Jeff Romano, Ali Reza Afshari, Ryan J. Chen, Xiangjun Chen, Fredrik Andreas Fineide, Ayyad Zartasht Khan, Tor Paaske Utheim, Niclas G. Karlsson, Gordon W. Laurie, Stacy Alyse Malaker

This study identifies new Gal-3 ligands in tear fluid, showing that lacritin's glycoforms and spliceoforms specifically bind Gal-3, influencing its biological functions.

bioRxiv · Nov 24, 2025 · PreprintBiochemistry

In-depth analysis of the tear fluid glycoproteome reveals diverse lacritin glycosylation and spliceoforms

Vincent Hung-Shu Chang, Keira E. Mahoney, Isaac Lian, Ryan J. Chen, Nara Chung, Tor Paaske Utheim, Niclas G. Karlsson, Stacy Alyse Malaker

This study uses mass spectrometry to analyze tear fluid glycoproteins, revealing novel glycosylation patterns and spliceoforms of lacritin and other clinically relevant proteins.

Journal of Biological Chemistry · Aug 8, 2025Peer-reviewedBiochemistry