Keira E. Mahoney

This study performs N-glycoproteomic profiling of Ancylostoma ceylanicum, identifying stage-specific glycoproteins and phosphorylcholine-modified glycans in larval and adult parasites.

This study investigates how site-specific O-glycans on lacritin influence its structure and multimerization, revealing their role in conformational flexibility and crosslinking residue positioning.

This paper maps mucin glycoforms in tumors using on-tissue digestion and mass spectrometry, revealing distinct glycosylation patterns in colorectal mucinous adenocarcinomas.

This study shows that loss of NgBR/cis-PTase function in the liver leads to fatty liver disease that progresses to hepatocellular carcinoma with 100% penetrance, and DGAT2 inhibition prevents this progression.

This paper develops a chemical genetic strategy to manipulate proteoglycan glycan attachment sites in mammalian cells using modified xylosyltransferases.

This study identifies new Gal-3 ligands in tear fluid, showing that lacritin's glycoforms and spliceoforms specifically bind Gal-3, influencing its biological functions.

This study uses mass spectrometry to analyze tear fluid glycoproteins, revealing novel glycosylation patterns and spliceoforms of lacritin and other clinically relevant proteins.

This study quantifies co-occupancy of N- and O-glycopeptides in mucins and other glycoproteins, showing higher prevalence in mucins and the need for electron-based methods for accurate site-specific analysis.

The paper optimizes a mucin-selective enrichment strategy to improve throughput, reduce sample input, and enhance glycopeptide signal for mucinome analysis.

The paper introduces BOCTAG, a method to label glycoproteins in specific cell types within mixed cultures, enabling analysis of cell-specific glycosylation.

This study compares glycoproteomics search algorithms, finding that O-Pair excels in O-glycopeptide identification while Byonic and pGlyco perform best for N-glycoproteomics.