Author

Isabelle Willoughby

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Cameron StewartiD· 3 shared Catherine TreicheliD· 3 shared David VeesleriD· 3 shared Elizabeth M. LeafiD· 3 shared Jack T. BrowniD· 3 shared Neil P. KingiD· 3 shared Adian Valdez· 2 shared Alexandra C. WallsiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Cameron StewartORCID

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Author profile →

3 papers

Recent·Most cited

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines

Amin Addetia, Alexandra Schäfer, Kaitlin R. Sprouse, Adian Valdez, Ashley Taylor, Mary-Jane Navarro, Jack T Brown, Elizabeth M. Leaf, Marcos C. Miranda, Alexandra C. Walls, Jimin Lee, Nicholas Catanzaro, Catherine Treichel, Isabelle Willoughby, John Powers, , David Veesler

This paper designs multivalent RBD nanoparticle vaccines that overcome immune imprinting and provide broad protection against SARS-CoV-2 variants and sarbecoviruses.

bioRxiv · May 11, 2025 · PreprintImmunology

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

Cara W. Chao, Kaitlin R. Sprouse, Marcos C. Miranda, Nicholas J. Catanzaro, Miranda L. Hubbard, Amin Addetia, Cameron Stewart, Jack T. Brown, Annie M. Dosey, Adian Valdez, Rashmi Ravichandran, Grace G. Hendricks, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, , Neil P. King

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

Cell Reports · Dec 1, 2024Peer-reviewedImmunology

Molecular basis of pathogenicity of the recently emerged FCoV-23 coronavirus

M. Alejandra Tortorici, Annette Choi, Cecily A. Gibson, Jimin Lee, Jack T Brown, Cameron Stewart, Anshu Joshi, Sheri Harari, Isabelle Willoughby, Catherine Treichel, Elizabeth M. Leaf, Jesse D. Bloom, Neil P. King, Christine Tait‐Burkard, Gary R. Whittaker, David Veesler

This study identifies molecular mechanisms of FCoV-23 pathogenicity, including receptor usage and biotype switching, and identifies a cross-reactive antibody for therapeutic development.

bioRxiv · Aug 25, 2024 · PreprintBiochemistry