CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics
K. Raychaudhuri, R. Rangu, A. Ma, N. Alvinez, A. D. Tran, S. Pallikkuth, K. M. McIntire, J. A. Garvey, J. Yi, L. E. Samelson
This study shows CD28 co-stimulation accelerates ZAP70 recruitment and activation in TCR microclusters by enhancing Lck dynamics and spatial separation of Lck species.
bioRxiv · Jun 27, 2024 · PreprintImmunology