A. D. Tran

EWSR1's visual modalities are defined by its association with nucleic acids and RNA polymerase II

This study identifies two visual modalities of EWSR1 in the nucleoplasm, both associated with nascent RNA, and shows EWSR1 foci localize to euchromatin and phosphorylated RNA polymerase II.

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs

This paper develops novel Chimeric Adapter Proteins (CAPs) that enhance T cell signaling and anti-tumor efficacy compared to conventional CAR-T cells.

Physics of sliding on water predicts morphological and behavioral allometry across a wide range of body sizes in water striders (Gerridae)

The paper models sliding physics on water to predict morphological and behavioral allometry in water striders across body sizes, confirming predictions with species observations.

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

This study shows that inhibiting SHP2 in endothelial cells reduces tumor growth by damaging the tumor vasculature, independent of SHP2 effects in tumor cells.

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.