A. Ma

CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics

This study shows CD28 co-stimulation accelerates ZAP70 recruitment and activation in TCR microclusters by enhancing Lck dynamics and spatial separation of Lck species.

Regulation of Chromatin Modifications through Coordination ofNucleus Size and Epithelial Cell Morphology Heterogeneity

The paper shows that cell morphology and nucleus size heterogeneity drive chromatin modification changes, affecting euchromatic and heterochromatic marks.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.

Characterization of the cytopathic effect of monkeypox virus isolated from clinical specimens and differentiation from common viral exanthems

The paper characterizes the cytopathic effect of monkeypox virus from clinical samples and differentiates it from other viral exanthems using cell culture.

Origin of Protein Quake: Energy Waves Conducted by a Precise Mechanical Machine

The paper identifies energy waves as the mechanism for redistributing heme energy in myoglobin after photolysis, showing they are more efficient than diffusion-based processes.

Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

Uncovering One-Dimensional Reaction Coordinate that Underlies Structure-Function Relationship of Proteins

The paper introduces a method to identify the one-dimensional reaction coordinate for protein dynamics, linking structure to function through a generalized work functional.

A Mechanism for the Rare Fluctuation that Powers Protein Conformational Change

The paper identifies a rare fluctuation mechanism that enables protein conformational changes by facilitating energy transfer through specific reaction coordinates.

Verticillium dahliae effector VDAL protects MYB6 from degradation by interacting with PUB25/26 E3 ligases for enhancing Verticillium wilt resistance in Arabidopsis

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

This study shows that inhibiting SETD8 reduces multiple myeloma cell survival and overcomes drug resistance regardless of p53 status.

The genetics and genome-wide screening of regrowth loci, a key component of perennialism in Zea diploperennis

This study identifies two dominant loci controlling regrowth after senescence in Zea diploperennis hybrids through genetic crosses and genome-wide screening.

The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

OTUB1 non-catalytically regulates the stability of the E2 ubiquitin conjugating enzyme UBE2E1

This study identifies a non-catalytic role of OTUB1 in stabilizing the E2 ubiquitin conjugating enzyme UBE2E1 by preventing its autoubiquitination and proteasomal degradation.

Stable networks of water-mediated interactions are conserved in activation of diverse GPCRs

The paper identifies conserved water-mediated interaction networks in GPCR activation across diverse receptors, with implications for drug design.