J. Yi

Single-cell resolved differentiation of pre-Kranz anatomy in maize leaf primordia

The paper uses single-nucleus RNA sequencing to study cell heterogeneity and developmental trajectories in maize leaf primordia, identifying potential regulators of Kranz anatomy development.

CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics

This study shows CD28 co-stimulation accelerates ZAP70 recruitment and activation in TCR microclusters by enhancing Lck dynamics and spatial separation of Lck species.

RFC1 AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVAS

The paper identifies and structures the G-quadruplex formed by RFC1 AAGGG repeats, showing its role in replication stalling and transcription inhibition in CANVAS.

Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

This study identifies distinct transcriptomic features in satellite cells of extraocular muscles that preserve neuromuscular junctions in ALS mice, suggesting potential therapeutic strategies.

Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs

This paper develops novel Chimeric Adapter Proteins (CAPs) that enhance T cell signaling and anti-tumor efficacy compared to conventional CAR-T cells.

A deep learning network for parallel self-denoising and segmentation in visible light optical coherence tomography of human retina

This paper introduces a deep learning framework for simultaneous self-denoising and segmentation of VIS-OCT retinal images, showing improved segmentation performance with reduced annotation requirements.

Second-generation dual-channel visible light optical coherence tomography enables wide-field, full-range, and shot-noise limited retinal imaging

This paper introduces a second-generation dual-channel VIS-OCT system that achieves wide-field, full-range, and shot-noise limited retinal imaging with improved depth resolution and SNR.

Spatiotemporal heterogeneity and the long-term impact of meteorological , environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging

The paper introduces Meso-OPM, a microscopy technique that enables large-scale 4D cellular resolution imaging of zebrafish larvae with improved axial resolution and field of view.

A Novel Oncogenic Function of PRC2 Heterogeneity in Medulloblastoma

This study shows that PRC2 heterogeneity in SHH medulloblastomas drives tumor growth through intrinsic and non-cell autonomous mechanisms involving IGF2.

Large field-of-view incoherent volumetric imaging in living human retina by confocal oblique scanning laser ophthalmoscopy

This paper introduces CoSLO, a technique for fast, large-field-of-view incoherent 3D retinal imaging in humans, achieving >20° viewing angle in 5 seconds with 45 microns depth resolution.

MG53 slows neuromuscular junction loss and prolongs survival in ALS

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

Brucella outer membrane proteins to control maturation and antigen presentation of mouse dendritic cells

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy

This paper introduces a label-free imaging cytometry method using deep learning to predict subcellular features from reflectance microscopy, achieving higher accuracy and throughput for single-cell analysis.

Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lens

This paper introduces a new variant of oblique plane microscopy (OPM) that achieves a large mesoscopic field-of-view for volumetric imaging, demonstrating its application on zebrafish larvae, mouse cortex, and C. elegans.

Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina

This study introduces a visible light OCTA system for human retinal imaging, achieving high-speed acquisition and microvascular oximetry with sub-100 μm vessel resolution.

Functional role of Polymerase IV during pollen development in Capsella

Loss of Polymerase IV function in Capsella rubella causes microspore arrest, revealing an important functional role of Polymerase IV during pollen development.

Volumetric fluorescence imaging in a human eye model by oblique scanning laser ophthalmoscope (oSLO): a feasibility study

Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification

This paper introduces a deep learning method for label-free optical oximetry that provides uncertainty quantification and demonstrates improved accuracy over traditional methods in rat retinal imaging.

High-speed volumetric fluorescein angiography (vFA) by oblique scanning laser ophthalmoscopy in mouse retina

This study uses oblique scanning laser ophthalmoscopy to perform high-speed volumetric fluorescein angiography in mouse retinas, enabling 3D visualization and quantification of capillary hemodynamics.

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

This study uses vnOCT to detect early retinal changes in a dexamethasone-induced ocular hypertension mouse model, finding that VN ratio and A-V sO2 correlate with RGC loss independent of IOP.

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

This study characterizes the caprine humoral immune response to Burkholderia pseudomallei during aerosol-induced melioidosis, identifying immunogenic proteins that may serve as diagnostic biomarkers.