CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.
P. Demetriou, E. Abu-Shah, S. McCuaig, V. Mayya, S. Valvo, K. Korobchevskaya, M. Friedrich, E. Mann, L. Y. Lee, T. Starkey, M. A. Kutuzov, J. Afrose, A. Siokis, Oxford IBD Cohort Investigators, M. Meyer-Hermann, , M. L. Dustin
The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.
bioRxiv · Mar 29, 2019 · PreprintImmunology