Author

L. Y. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

T. Starkey· 2 shared A. Bassett· 1 shared A. C. Hurt· 1 shared A. Everest-Dass· 1 shared A. J. Lewis· 1 shared A. Siokis· 1 shared B. Clinch· 1 shared C. Woolley· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

T. Starkey

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 8, 2021

Oligomannosylation and MAN1A1 expression associate strongly with a subset of human cancer types

S. Chatterjee, R. Kawahara, J. Ugonotti…·M. Thaysen-Andersen

The paper identifies oligomannosylation and MAN1A1 expression as strongly associated with specific human cancers through glycomics analysis and MALDI-MS imaging.

DOI 10.1101/2021.05.08.443254

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivSep 28, 2020

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

L. Y. Lee, J. Zhou, P. Koszalka…·A. C. Hurt

The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.

DOI 10.1371/journal.ppat.1009527

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 18, 2019

A CRISPR Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis That Acts Through Reduced mTOR Signalling

L. Y. Lee, C. Woolley, T. Starkey…·I. Tomlinson

DOI 10.1101/613356

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologybioRxivPreprintMar 29, 2019

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

P. Demetriou, E. Abu-Shah, S. McCuaig…·M. L. Dustin

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.

DOI 10.1101/589440

humanbulk RNA-seq

𝕏 PostBluesky