M. Friedrich

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

This study shows that intestinal epithelial cells expressing MHC II modulate CD4 T cell responses during intestinal inflammation, dampening pro-inflammatory effector Th cells.

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells

This study shows HDAC7 regulates CD8+ T cell function by controlling survival, calcium homeostasis, and memory responses, impacting anti-viral and anti-tumor immunity in mice.

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

Dual-color Fluorescence Cross-Correlation Spectroscopy to study Protein-Protein Interaction and Protein Dynamics in Live Cells

This paper presents a protocol for dual-color FCCS and FRET to study membrane receptor dynamics in live cells, using open-source software and providing step-by-step data analysis.

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

This study shows that Grem1 antagonizes BMP signaling to regulate epithelial cell fate during intestinal regeneration.

Centrosome impairment causes DNA replication stress through MLK3/MK2 signaling and R-loop formation

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

This study investigates how TCR and inflammatory signals shape human MAIT cell functions, revealing their roles in tissue repair and effector responses.

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.