M. L. Dustin

Inheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development

This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

The kinase occupancy of T-cell coreceptors reconsidered

The paper re-evaluates kinase occupancy of T-cell coreceptors CD4 and CD8β, finding CD4-Lck interaction is stoichiometric while CD8β-Lck is substantial, with structural differences influencing binding.

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

Artificial Antigen Presenting Cells for Detection and Desensitisation of Auto-reactive T cells Associated with Type 1 Diabetes

This paper develops artificial antigen presenting cells (aAPCs) to detect and desensitize autoreactive T cells in type 1 diabetes, showing effectiveness in human and mouse models.

The Bardet-Biedl Syndrome complex component BBS1 regulates proteasome-dependent F-actin clearance from the centrosome to enable its translocation to the T cell immune synapse

In silico characterization of mechanisms positioning costimulatory and checkpoint complexes in immune synapses

The paper uses computer simulations to reveal how immunoglobulin superfamily adhesion and costimulatory/checkpoint complexes are localized in immunological synapses.

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

This paper develops a tissue-like platform to study interactions between engineered quiescent human T-cells and dendritic cells, demonstrating CD4 help and PD-1 checkpoint blockade effects.

Single-cell glycolytic activity regulates membrane tension 1 and HIV-1 fusion

This study links host cell glycolytic activity to membrane tension and shows how it affects HIV-1 fusion in single cells.

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells

The paper identifies synaptic ectosomes released by helper T cells that contain TCR and CD40L, enabling dendritic cell maturation and cytokine production.

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.

Synapse propensity of human memory CD8 T cells confers competitive advantage over naïve counterparts

The paper shows human memory CD8 T cells have higher synapse propensity than naive cells, giving them competitive advantage in immune responses.

Reconstitution of immune cell interactions in free-standing membranes

The paper presents an in vitro system using synthetic vesicles to study spatiotemporal aspects of immune synapse formation and signaling molecule distribution in T cells.