Metformin improves glycemia independently of skeletal muscle AMPK via enhanced intestinal glucose clearance
R. Kjobsted, J. M. Kristensen, J. B. Birk, N. O. Jorgensen, K. Kido, N. R. Andersen, J. K. Larsen, M. Foretz, V. Benoit, F. Nielsen, K. Brosen, N. Jessen, Y. Hellsten, K. Hojlund, J. F. P. Wojtaszewski
This study shows metformin reduces blood glucose through improved intestinal glucose clearance, not via skeletal muscle AMPK activation, challenging current understanding of its mechanism.
bioRxiv · May 22, 2022 · PreprintPhysiology