MicrobiologybioRxiv
Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
D. Olagnier, E. Farahani, J. Thyrsted…·C. K. Holm
The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.
DOI 10.1038/s41467-020-18764-3