Author

J. B. Lucks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:E. coli· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

E. J. Strobel· 3 shared L. Cheng· 3 shared A. A. Chen· 2 shared A. M. Yu· 2 shared B.-K. Cho· 1 shared D. Stranford· 1 shared D. Z. Bushhouse· 1 shared E. N. White· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

E. J. Strobel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

RNA folding kinetics control riboswitch sensitivity in vivo

D. Z. Bushhouse, J. Fu, J. B. Lucks

The paper shows that slowing RNA folding kinetics enhances riboswitch sensitivity in vivo and identifies general principles for programming RNA folding dynamics.

bioRxiv · Mar 29, 2024Biochemistry

Zur and Zinc Increase Expression of E. coli Ribosomal Protein L31 Through RNA-Mediated Repression of the Repressor L31p

R. A. Rasmussen, J. M. Caramillo, V. Sosnowski, B.-K. Cho, Y. A. Goo, J. B. Lucks, T. V. O'Halloran

The paper shows Zur up-regulates E. coli ribosomal protein L31 by repressing its paralogue L31p through RNA hairpin-mediated translational repression.

bioRxiv · May 27, 2022Biochemistry

Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells

D. Stranford, L. M. Simons, K. Berman, L. Cheng, J. B. Lucks, J. F. Hultquist, J. N. Leonard

This paper develops methods to engineer extracellular vesicles for targeted delivery of biologics to T cells, demonstrating efficient cargo delivery using Cas9-sgRNA complexes.

bioRxiv · May 14, 2022Bioengineering

Cotranscriptional RNA strand exchange underlies the gene regulation mechanism in a purine-sensing transcriptional riboswitch

L. Cheng, E. N. White, N. L. Brandt, A. M. Yu, A. A. Chen, J. B. Lucks

The paper investigates how ligand binding induces conformational changes in a purine-sensing riboswitch by stabilizing intermediate structures through strand exchange processes.

bioRxiv · Oct 25, 2021Biochemistry

Chemical transcription roadblocking for nascent RNA display

E. J. Strobel, J. T. Lis, J. B. Lucks

This paper introduces a chemical method to block RNA polymerase transcription in E. coli using DNA modifications, enabling stable nascent RNA display in minimal in vitro reactions.

bioRxiv · Dec 26, 2019Biochemistry

A mechanism for ligand gated strand displacement in ZTP riboswitch transcription regulation

E. J. Strobel, L. Cheng, K. E. Berman, P. D. Carlson, J. B. Lucks

This study identifies the cotranscriptional folding pathway and regulatory mechanism of the Clostridium beijerinckii pfl riboswitch in response to ZMP.

bioRxiv · Feb 12, 2019 · PreprintBiochemistry

Computationally Reconstructing Cotranscriptional RNA Folding Pathways from Experimental Data Reveals Rearrangement of Non-Native Folding Intermediates

A. M. Yu, P. M. Gasper, E. J. Strobel, K. E. Watters, A. A. Chen, J. B. Lucks

This paper introduces R2D2, a method to predict RNA folding pathways from cotranscriptional SHAPE-Seq data, revealing non-native intermediates in E. coli SRP RNA folding.

bioRxiv · Jul 28, 2018Biochemistry