L. Cheng

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

MAGNETICALLY STEERED CELL THERAPY FOR REDUCTION OF INTRAOCULAR PRESSURE AS A TREATMENT STRATEGY FOR OPEN-ANGLE GLAUCOMA

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

Circadian control of kidney regeneration via Lima1-mediated regulation of EMT

This study investigates the role of circadian clock genes in kidney regeneration using zebrafish, finding that per1 and nr1d1 promote regeneration by repressing lima1a, which regulates EMT.

Cyclocarya paliurus polysaccharides improve high fat diet-fed mice lipid dysmetabolism through gut microbiota

This study shows Cyclocarya paliurus polysaccharides reduce obesity and lipid dysmetabolism in high fat diet-fed mice by modulating gut microbiota.

Rice OsPLATZ3 controls ROS homeostasis by inhibiting ROS-Scavenging Activity during Tapetum Degeneration

This study identifies OsPLATZ3 as a regulator of ROS homeostasis during tapetum degeneration in rice, showing its role in suppressing ROS scavenging and causing male sterility.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

GTPase-activating protein ARAP1 regulates circular dorsal ruffles as a nutrient uptake mechanism in the Hep3B hepatocellular carcinoma cell line

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

Machine Learning Elucidates Design Features of Plasmid DNA Lipid Nanoparticles for Cell Type-Preferential Transfection

This study uses machine learning to identify LNP composition parameters that enhance transfection efficiency across cell types and modulate cell type-preferentiality.

Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in ataxia telangiectasia

This study uses bulk RNA-seq to identify inflammatory phenotypes in ataxia telangiectasia by analyzing peripheral blood mononuclear cells.

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

The paper links adverse social determinants of health to NK cell dysfunction through obesity, LDL, and DUSP1 signaling in African-American women.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

An all-atom protein generative model

This paper introduces an all-atom diffusion model for protein structure generation that co-designs structure and sequence, producing high-quality proteins with accurate sidechain behavior.

Single-Cell Phylogenetic Tracing Maps the Landscape of Human Tumor Immune Cell Plasticity Driven by Microenvironment Factors-Mediated Epigenetic Reprogramming

This study maps immune cell plasticity in human tumors using lineage tracing and reveals microenvironment-driven epigenetic reprogramming as a key mechanism.

Mechanisms of transcription control by distal enhancers from high-resolution single-gene imaging

This study uses single-gene imaging to investigate how distal enhancers control promoters over long distances, revealing that enhancer-promoter interactions occur at 200 nm and involve transcription factor clusters that increase transcriptional bursting frequency.

Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

Diclofenac and other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are Competitive Antagonists of the human P2X3 Receptor

This study identifies diclofenac and other NSAIDs as competitive antagonists of the human P2X3 receptor, with diclofenac showing strong inhibition of hP2X3R and hP2X2/3R.

The roles and evolution of the four LEAFY homologues in floral patterning and leaf development in woodland strawberry

This study identifies the functional roles and evolutionary divergence of four LFY homologues in woodland strawberry, showing that only FveLFYa is critical for floral patterning.

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale metabolic modeling.

This study uses HRMAS 13C NMR and genome-scale metabolic modeling to analyze dynamic anaerobic metabolism in Clostridioides difficile, revealing metabolic integration of glycolytic and amino acid fermentation pathways.

Myeloid cell evolution uncovered by shrimp immune cell analysis at single-cell resolution

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells

This paper develops methods to engineer extracellular vesicles for targeted delivery of biologics to T cells, demonstrating efficient cargo delivery using Cas9-sgRNA complexes.

Ancestral Body Plan and Adaptive Radiation of Sauropterygian Marine Reptiles

This study describes an Early Triassic sauropterygian skeleton, identifies its phylogenetic position, and highlights the ancestral body plan and adaptive radiation of marine reptiles.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Optical control of CRISPR-Cas editing with cyclically caged guide RNAs

This paper introduces a method to control CRISPR-Cas gene editing using light-activated circular guide RNAs, enabling precise spatial and temporal gene editing in cells and embryos.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.