BiochemistrybioRxiv
Computationally Reconstructing Cotranscriptional RNA Folding Pathways from Experimental Data Reveals Rearrangement of Non-Native Folding Intermediates
A. M. Yu, P. M. Gasper, E. J. Strobel…·J. B. Lucks
This paper introduces R2D2, a method to predict RNA folding pathways from cotranscriptional SHAPE-Seq data, revealing non-native intermediates in E. coli SRP RNA folding.
DOI 10.1016/j.molcel.2020.12.017