Author

J. B. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. R. Brender· 4 shared K. Yamamoto· 4 shared M. C. Krishna· 4 shared S. Kishimoto· 4 shared Y. Saida· 4 shared G. V. Chandramouli· 2 shared N. Devasahayam· 2 shared Y. Otowa· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCancer Biology

J. R. Brender

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4 papers

Recent·Most cited

Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair

Y. Otowa, S. Kishimoto, Y. Saida, K. Yamashita, K. Yamamoto, G. V. Chandramouli, N. Devasahayam, J. B. Mitchell, M. C. Krishna, J. R. Brender

This study shows that evofosfamide and gemcitabine work together in pancreatic cancer xenografts by improving tumor oxygenation and inhibiting DNA repair, with effects varying by tumor type.

Antioxidants & Redox Signaling · Sep 1, 2023Peer-reviewedCancer Biology

PEGPH20, a PEGylated Human Hyaluronidase, Induces Radiosensitization by Reoxygenation In Pancreatic Cancer Xenografts. A Molecular Imaging Study

T. Seki, Y. Saida, S. Kishimoto, J. Lee, Y. Otowa, K. Yamamoto, G. V. Chandramouli, N. Devasahayam, J. B. Mitchell, J. R. Brender, M. C. Krishna

This study shows PEGPH20 improves radiation therapy efficacy in pancreatic cancer tumors with high hyaluronan by increasing oxygenation, as measured by multiple imaging techniques.

bioRxiv · Jan 11, 2022Cancer Biology

Detecting Early Response to Immune Checkpoint Blockade by Multimodal Molecular Imaging

Y. Saida, J. R. Brender, K. Yamamoto, J. B. Mitchell, M. C. Krishna, S. Kishimoto

This study uses multimodal imaging to detect early response to immune checkpoint blockade therapy in tumor models, identifying imaging biomarkers for treatment assessment.

Cancer Research · Jul 1, 2021Peer-reviewedCancer Biology

Reoxygenation after Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts is due to Decreased Oxygen Consumption and not Increased Oxygen Supply

S. Kishimoto, j. R. Brender, Y. Saida, K. Yamamoto, J. B. Mitchell, M. C. Krishna

This study shows evofosfamide treatment reduces tumor hypoxia by decreasing oxygen consumption, not increasing oxygen supply, using pO2 imaging in xenograft models.

bioRxiv · May 16, 2020 · PreprintCancer Biology