J. R. Brender

This study shows that evofosfamide and gemcitabine work together in pancreatic cancer xenografts by improving tumor oxygenation and inhibiting DNA repair, with effects varying by tumor type.

This study compares two spin probes for oxygen measurement in vivo, finding Ox071 more sensitive and capable of a broader pO2 range.

This study shows PEGPH20 improves radiation therapy efficacy in pancreatic cancer tumors with high hyaluronan by increasing oxygenation, as measured by multiple imaging techniques.

This study uses multimodal imaging to detect early response to immune checkpoint blockade therapy in tumor models, identifying imaging biomarkers for treatment assessment.

This study shows evofosfamide treatment reduces tumor hypoxia by decreasing oxygen consumption, not increasing oxygen supply, using pO2 imaging in xenograft models.

This study compares trehalose and glycerol as glassing agents in DNP MRI, finding trehalose provides faster polarization with similar effectiveness and fewer metabolic perturbations.

The paper identifies a partially folded insulin intermediate involved in aggregation at acidic pH and describes its structural features that may promote oligomer formation.