Characterising the Protein-Protein Interaction Between MDM2 and 14-3-3σ; Proof of Concept for Small Molecule Stabilisation
J. A. Ward, B. Romartinez-Alonso, D. F. Kay, J. Bellamy-Carter, B. Thurairajah, J. Basran, H. Kwon, A. C. Leney, S. Macip, P. Roversi, F. W. Muskett, R. G. Doveston
This paper characterises the phosphorylation-dependent interaction between 14-3-3σ and MDM2 and shows that small molecule stabilisation of this PPI is feasible using fusicoccin A.
bioRxiv · Sep 26, 2023Biochemistry