BiochemistrybioRxiv
Characterising the Protein-Protein Interaction Between MDM2 and 14-3-3σ; Proof of Concept for Small Molecule Stabilisation
J. A. Ward, B. Romartinez-Alonso, D. F. Kay…·R. G. Doveston
This paper characterises the phosphorylation-dependent interaction between 14-3-3σ and MDM2 and shows that small molecule stabilisation of this PPI is feasible using fusicoccin A.
DOI 10.1016/j.jbc.2024.105651