H. Kwon

TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae

This study identifies a conserved TNF signaling pathway in Anopheles gambiae that regulates immune cell function and limits Plasmodium parasite survival.

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

Mosquito immune cells enhance dengue and Zika virus dissemination in Aedes aegypti

This study shows mosquito immune cells help spread dengue and Zika viruses in Aedes aegypti, supporting a 'trojan horse' model of virus dissemination.

Characterising the Protein-Protein Interaction Between MDM2 and 14-3-3σ; Proof of Concept for Small Molecule Stabilisation

This paper characterises the phosphorylation-dependent interaction between 14-3-3σ and MDM2 and shows that small molecule stabilisation of this PPI is feasible using fusicoccin A.

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host

This paper shows that extracellular vesicles from Brugia malayi microfilariae reduce melanization in Aedes aegypti mosquitoes by downregulating AAEL002590 and decreasing phenoloxidase activity.

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

Fast volumetric imaging with line-scan confocal microscopy by an electro-tunable lens

This paper introduces an electro-tunable lens in line-scan confocal microscopy to enable fast volumetric imaging with high acquisition rates and depth resolution.

Identification of a prostaglandin E2 receptor that regulates mosquito oenocytoid immune cell function in limiting bacteria and parasite infection

This study identifies a prostaglandin E2 receptor in mosquitoes that modulates immune cell function to limit bacterial and Plasmodium infection.

Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation

The paper uses scRNA-seq to identify immune cell subtypes and differentiation in mosquitoes, defining markers and showing the role of lozenge in oenocytoid fate.

The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor

This study shows that halofenozide, a 20-hydroxyecdysone agonist, reduces Plasmodium infection in Anopheles gambiae by activating the ecdysone receptor via ultraspiracle, without affecting cellular immunity or AMP production.

Optimized residue analysis method for broflanilide and its metabolites in agricultural produce using the QuEChERS method and LC-MS/MS

The paper optimizes a method for detecting broflanilide and its metabolites in agricultural products using QuEChERS and LC-MS/MS, achieving reliable recoveries and low matrix effects.

Distinct CD8+ T Cell Programming in the Tumor Microenvironment Contributes to Sex Bias in Bladder Cancer Outcome

The paper identifies sex differences in CD8+ T cell programming in bladder cancer, showing male-biased T cell exhaustion and implications for immune checkpoint therapy.

Fluorescent Sp3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses

20-hydroxyecdysone (20E) primes innate immune responses that limit bacteria and malaria parasite survival in Anopheles gambiae

This study shows that 20-hydroxyecdysone primes immune responses in Anopheles gambiae, reducing bacteria and Plasmodium survival.

Malaria parasite immune evasion and adaptation to its mosquito host is influenced by the acquisition of multiple blood meals

This study shows that additional blood meals affect Plasmodium parasite development differently in Anopheles mosquitoes, influencing oocyst numbers and immune evasion.

Loop-mediated isothermal amplification assay for Enterococcus sp., E. coli and S. aureus in chicken

The paper develops LAMP assays for detecting Enterococcus sp., E. coli, and S. aureus in chicken to diagnose bacterial chondronecrosis with osteomyelitis.