Depletion of the AD risk gene SORL1 selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing
A. Knupp, S. Mishra, R. Martinez, J. Braggin, M. Szabo, D. W. Hailey, S. A. Small, S. Jayadev, J. E. Young
This study shows that SORL1 depletion in neurons causes endosome enlargement, a key AD hallmark, without affecting amyloidogenic APP processing.
bioRxiv · Jan 6, 2020Cell Biology