The Alzheimer's gene SORL1 is a key regulator of endosomal traffic and recycling in human neurons
S. Mishra, A. Knupp, M. Szabo, C. A. Williams, C. Kinoshita, D. W. Hailey, Y. Wang, J. E. Young
This study shows SORL1 regulates endosomal recycling in neurons by affecting APP, TRKB, and GLUA1 trafficking, with implications for Alzheimer's disease.
bioRxiv · Jul 26, 2021Cell Biology