Heterologous production of 1-tuberculosinyladenosine in Mycobacterium kansasii models pathoevolution towards the transcellular lifestyle of Mycobacterium tuberculosis.
M. Ghanem, J.-Y. Dube, J. Wang, F. McIntosh, D. Houle, P. Domenech, M. B. Reed, S. Raman, J. Buter, A. J. Minnaard, B. Moody, M. A. Behr
This study introduces the M. tuberculosis-specific gene pair into M. kansasii to model pathoevolution, finding that 1-TbAd production enhances early infection but impairs long-term survival.
bioRxiv · Apr 25, 2020Microbiology