AraC binds the p75NTR transmembrane domain to induce neurodegeneration in mature neurons.
V. S. Lopes Rodrigues, P. Boxy, E. Sim, D. I. Park, A. Andersson, D. Fernandez-Suarez, J. Carbonell, A. Nykjaer, L. Kisiswa
This study shows AraC binds p75NTR's transmembrane domain, causing neurodegeneration in mature neurons by disrupting NFκB signaling and activating JNK-mediated cell death.
bioRxiv · Dec 1, 2021 · PreprintCell Biology