Author

E. Sim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:experimental assay· 3 Organism:mouse· 3 Assay:whole-genome sequencing· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:variant calling· 2

Frequent Co-Authors

V. Sintchenko· 4 shared C. Lam· 2 shared V. Timms· 2 shared A. Andersson· 1 shared A. Arnott· 1 shared A. Nykjaer· 1 shared B. J. Marais· 1 shared C. F. Ibanez· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

V. Sintchenko

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants

X. Zhang, C. Lam, E. Martinez, E. Sim, T. Crighton, B. J. Marais, V. Sintchenko

The paper identifies drug-resistant minority variants in Mycobacterium tuberculosis populations and shows their association with mixed strain populations and treatment outcomes.

bioRxiv · Apr 19, 2023 · PreprintMicrobiology

Can genomics and meteorology predict outbreaks of legionellosis in urban settings?

V. J. Timms, E. Sim, K. Pey, V. Sintchenko

This study investigates the role of genomics and meteorology in predicting Legionnaires disease outbreaks in urban areas, finding that cgMLST typing is effective for outbreak investigation but weather patterns are not strongly linked to the dominant outbreak clone.

bioRxiv · Sep 26, 2022Microbiology

AraC binds the p75NTR transmembrane domain to induce neurodegeneration in mature neurons.

V. S. Lopes Rodrigues, P. Boxy, E. Sim, D. I. Park, A. Andersson, D. Fernandez-Suarez, J. Carbonell, A. Nykjaer, L. Kisiswa

This study shows AraC binds p75NTR's transmembrane domain, causing neurodegeneration in mature neurons by disrupting NFκB signaling and activating JNK-mediated cell death.

bioRxiv · Dec 1, 2021 · PreprintCell Biology

Genomic evaluation of Bordetella spp. originating from Australia

W. Fong, V. Timms, E. Sim, V. Sintchenko

This study evaluates genomic changes in Bordetella spp. from Australia using long-read sequencing to close genomes and assess their relationship with global isolates.

bioRxiv · Mar 2, 2021 · PreprintMicrobiology

Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7

R. Srivastava, E.-S. Lee, E. Sim, C.-S. New, C. F. Ibanez

This study shows that combining ALK7 inhibition with lifestyle or anti-inflammatory interventions leads to sustained weight loss in obese mice, even under high caloric intake.

bioRxiv · Jul 28, 2020Physiology

A Small interfering RNA lead targeting RNA-dependent RNA-polymerase effectively inhibit the SARS-CoV-2 infection in Golden Syrian hamster and Rhesus macaque

S. H. Gu, C. H. Yu, Y. Song, N. Y. Kim, E. Sim, J. Y. Choi, D. H. Song, G. H. Hur, Y. K. Shin, S. T. Jeong

The paper screens siRNA molecules to target SARS-CoV-2 and shows that an RdRp-targeting siRNA reduces infection in hamsters and macaques.

bioRxiv · Jul 7, 2020 · PreprintMicrobiology

REVEALING COVID-19 TRANSMISSION BY SARS-CoV-2 GENOME SEQUENCING AND AGENT BASED MODELLING

R. J. Rockett, A. Arnott, C. Lam, R. Sadsad, V. Timms, K.-A. Gray, J.-S. Eden, S. L. Chang, M. Gall, J. Draper, E. Sim, N. L. Bachmann, I. Carter, K. Basile, R. Byun, , V. Sintchenko

The paper uses SARS-CoV-2 genome sequencing and agent-based modeling to estimate local transmission rates during the early stages of the COVID-19 outbreak in New South Wales.

bioRxiv · Apr 19, 2020 · PreprintMicrobiology