Glycan-specific IgM is critical for human immunity to Staphylococcus aureus
A. Hendriks, P. F. Kerkman, M. R. Varkila, J. L. Haitsma-Mulier, S. Ali, T. ten Doesschate, T. W. van der Vaart, C. J. C. de Haas, P. C. Aerts, O. L. Cremer, M. J. Bonten, V. Nizet, G. Y. Liu, J. D. C. Codee, S. H. Rooijakkers, , N. M. van Sorge
This study identifies WTA-specific IgM as a critical immune factor for human protection against S. aureus, outperforming IgG in opsonophagocytic activity and correlating with clinical outcomes.
bioRxiv · Jul 14, 2023 · PreprintMicrobiology