S. Ali

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

A dynamin-like protein in the human malaria parasite plays an essential role in mitochondrial homeostasis and fission during asexual blood stages

This study identifies PfDyn2, a dynamin-like protein in P. falciparum, essential for mitochondrial fission and homeostasis during asexual blood stages of malaria.

Deep learning methods to forecasting human embryo development in time-lapse videos

This paper introduces an AI system that forecasts future embryo morphology in time-lapse videos using Convolutional LSTM layers, showing accurate predictions for cleavage and blastocyst stages.

Peptide-based capture-and-release purification of extracellular vesicles and statistical algorithm enabled quality assessment

This paper introduces a peptide-based EV isolation method and a statistical algorithm to assess EV quality, showing improved identification of tumor markers in pancreatic cancer samples.

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER calcium homeostasis involved in neuronal differentiation.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells

The paper shows BATF suppresses IFN I production in pDCs via DC-SCRIPT, revealing a negative feedback loop in antiviral immunity.

Early life regulatory T cells modulate PPAR-gamma dependent skin pigmentation

The paper shows that early life regulatory T cells (ETregs) regulate PPAR-gamma signaling in hair follicles, which is essential for melanocyte stem cell-mediated skin pigmentation.

CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss

The paper develops a scalable microfluidic electroporation system to load gRNA:Cas9 RNP complexes into extracellular vesicles, achieving effective gene therapy for hearing loss in a mouse model.

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

This study identifies WTA-specific IgM as a critical immune factor for human protection against S. aureus, outperforming IgG in opsonophagocytic activity and correlating with clinical outcomes.

β-ionone regulates Arabidopsis thaliana transcriptome and increases its resistance against Botrytis cinerea

This study shows that β-ionone reprograms Arabidopsis transcriptome and enhances resistance to Botrytis cinerea through hormone modulation and stress response activation.

BBIBP-CorV (Sinopharm) vaccination- induced immunity is affected by age, gender and prior COVID-19 and activates responses to spike and other antigens

This study examines how BBIBP-CorV vaccination-induced immunity varies with age, gender, and prior COVID-19, showing differential antibody and T cell responses to SARS-CoV-2 antigens.

Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice

This study identifies impaired SR Ca2+ signaling and disrupted ion channel activity in Col4a1 mutant mice as contributors to age-related cerebral small vessel disease.

Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members

This study shows TMEM163 forms functional heterodimers with ZNT1-ZNT4 proteins, influencing zinc efflux activity through homodimer and heterodimer interactions.

The Arabidopsis D27like1 is a novel Isomerase that Contributes to SL Biosynthesis and Negatively Impacts ABA Level

This paper identifies AtD27-like1 as a cis/cis-{beta}-carotene isomerase that contributes to strigolactone biosynthesis and negatively affects ABA levels in Arabidopsis.

Canonical Strigolactones Are Not the Tillering-Inhibitory Hormone but Rhizospheric Signals in Rice

This study shows canonical strigolactones in rice are not responsible for shoot branching inhibition but act as rhizospheric signals to influence Striga germination and mycorrhizal colonization.

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: maintenance of mitochondrial homeostasis and induction of apoptosis like cell death under cellular stress

This study identifies PfHtrA2's dual role in maintaining mitochondrial homeostasis and inducing apoptosis-like cell death in Plasmodium falciparum under stress.

An actin-like filament from Clostridium botulinum exhibits a novel mechanism of filament dynamics

The paper identifies a ParM protein from Clostridium botulinum that forms a double-stranded filament with unique dynamics involving Pi-induced lateral shifts and distinct interactions with ParR.

The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway

This study identifies Beauvericin as an activator of dendritic cells via the TLR4 signaling pathway, suggesting its potential as a vaccine adjuvant or cancer immunotherapy.

COEVOLUTION WITH SPATIALLY STRUCTURED RICE LANDRACES MAINTAINS MULTIPLE GENERALIST LINEAGES IN THE RICE BLAST PATHOGEN

The paper examines the coevolution between rice landraces and their blast pathogen in China, finding that generalist pathogen lineages coexist with host genetic subdivision.

Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution

This study presents the structure of Odinarchaeota tubulin and shows it forms tubules similar to FtsZ, suggesting it is an evolutionary intermediate between prokaryotic and eukaryotic microtubule-forming proteins.

Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

The paper identifies IGFBP3 as a secreted protein that spatially coordinates IGF signaling to promote neonatal cardiac regeneration.

Active growth signalling promotes cancer cell sensitivity to the CDK7 inhibitor ICEC0942

This study identifies active mTOR signaling and cell growth as predictors of cancer cell sensitivity to the CDK7 inhibitor ICEC0942.

Sugar Beet Extract Acts as a Natural Bio-Stimulant for Physio-Biochemical analysis of Hordeum Vulgare L. under Induced Salinity Stress

This study evaluates sugar beet extract's ability to mitigate salinity stress effects on barley growth and physiological traits.

Peripheral Coupling Sites Formed by STIM1 Govern the Contractility of Vascular Smooth Muscle Cells

This study shows that STIM1 maintains peripheral coupling in vascular smooth muscle cells, essential for contractility, independent of ER Ca2+ store depletion.

BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damage

This study shows BKPyV infection increases APOBEC3-mediated genomic damage in urothelial cells, contributing to bladder cancer risk in immunocompromised individuals.

REGEN-COV protects against viral escape in preclinical and human studies

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

Effect of exogenously applied alpha-tocopherol on vital agronomic, physiological and biochemical attributes of Lentil (Lens culinaris Medik.) under induced drought stress

This study shows that applying alpha-tocopherol to lentils under drought stress improves growth, physiological, and biochemical traits by reducing oxidative stress and enhancing stress tolerance.

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.