J. D. Dougherty

Extensive characterization of a Williams Syndrome murine model shows Gtf2ird1-mediated rescue of select sensorimotor tasks, but no effect on enhanced social behavior

This study characterizes a Williams Syndrome mouse model, showing Gtf2ird1 overexpression rescues some sensorimotor tasks but not social behavior.

A comprehensive assay of social motivation reveals sex-differential roles of ASC-associated genes and oxytocin

This paper develops a new social motivation assay in mice to study sex-differential roles of ASC-associated genes and oxytocin, finding distinct vulnerabilities in males and females.

X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and harvest index

The paper uses X-ray CT to analyze annual rings in 30-year-old wine grape vines, showing rootstocks affect secondary growth and harvest index over time.

Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model

This study investigates whether oxytocin receptor dysregulation contributes to fear memory deficits in a Williams Syndrome mouse model, finding no rescue of fear responses with an oxytocin receptor antagonist.

Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders

This study compares gait abnormalities in two mouse models of neurodevelopmental disorders across development and finds shared and disorder-specific gait features that change over time.

The trajectory of gait development in mice

This study develops a standardized gait assay for mice and characterizes the developmental trajectory of gait in two strains, highlighting strain-specific features and parallels with human gait development.

Gtf2i and Gtf2ird1 mutation are not sufficient to reproduce mouse phenotypes caused by the Williams Syndrome critical region

This study shows that mutations in Gtf2i and Gtf2ird1 alone cannot reproduce the phenotypes of Williams syndrome caused by deletion of the WSCR region.

Erroneous inference based on a lack of preference within one group: autism, mice, and the Social Approach Task.

The paper identifies and addresses erroneous statistical practices in analyzing Social Approach Task data from autism mouse models, showing how incorrect methods increase false positives and proposing a solution.