Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice
Y. Barekatain, S. Khadka, K. Harris, J. Delacerda, V. C. Yan, K.-C. Chen, C.-D. Pham, M. N. Uddin, R. Avritcher, E. J. Eisenberg, R. Kalluri, S. W. Millward, F. L. Muller
The paper quantifies phosphonate drugs using 1H-31P HSQC NMR, showing rats provide better drug exposure models than mice for phosphonate-containing compounds.
bioRxiv · Jan 30, 2022Pharmacology & Toxicology