Author

K.-C. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. A. S. Tavares· 1 shared A. Lovdel· 1 shared A. M. Johnstone· 1 shared B. J. Thomas· 1 shared C. Fyfe· 1 shared C. J. Alcaide-Corral· 1 shared C.-C. Peng· 1 shared C.-D. Pham· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPhysiology

A. A. S. Tavares

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Author profile →

4 papers

Recent·Most cited

Reduced glutamate decarboxylase 1 underlies morphine-promoted lung metastasis of triple-negative breast cancer in mice

S. H. Chen, C.-H. Shih, T.-L. Ke, C.-N. Hsiung, K.-C. Chen, Z.-X. Huang, T.-H. Chuang, L.-K. Chen, L. Chen

This study shows that long-term morphine use in mice increases lung metastasis of triple-negative breast cancer by reducing GAD1 and taurine biosynthesis, suggesting taurine may counteract this effect.

bioRxiv · Sep 14, 2023 · PreprintCancer Biology

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

K. J. Suchacki, B. J. Thomas, Y. M. Ikushima, K.-C. Chen, C. Fyfe, A. A. S. Tavares, H. J. Woodward, R. J. Sulston, A. Lovdel, X. Han, D. Mattiucci, E. J. Brain, H. Kobayashi, G. A. Gray, P. D. Whitfield, , W. P. Cawthorn

This study investigates how caloric restriction affects adipose tissue and metabolic health, finding that its benefits are sex- and age-dependent in mice and humans.

bioRxiv · Feb 20, 2022Physiology

Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice

Y. Barekatain, S. Khadka, K. Harris, J. Delacerda, V. C. Yan, K.-C. Chen, C.-D. Pham, M. N. Uddin, R. Avritcher, E. J. Eisenberg, R. Kalluri, S. W. Millward, F. L. Muller

The paper quantifies phosphonate drugs using 1H-31P HSQC NMR, showing rats provide better drug exposure models than mice for phosphonate-containing compounds.

bioRxiv · Jan 30, 2022Pharmacology & Toxicology

Nifedipine Modulated Renal Lipogenesis via AMPK-SREBP Transcriptional Pathways

Y.-C. Lin, M.-S. Wu, C.-R. Chen, C.-Y. Chen, C.-J. Chen, K.-C. Chen, C.-C. Peng

This study shows nifedipine induces renal lipotoxicity by activating the AMPK-SREBP pathway, leading to lipid accumulation and renal damage.

bioRxiv · Dec 4, 2018 · PreprintBiochemistry