K. Harris

Effects of parental age and polymer composition on short tandem repeat de novo mutation rates

The paper investigates how parental age and STR composition affect de novo mutation rates, finding that maternal age influences STR mutations even when oocytes are not replicating.

Population size interacts with reproductive longevity to shape the germline mutation rate

The paper examines how reproductive longevity interacts with population size to shape germline mutation rates, finding that longer reproductive ages reduce mutation rates per year in sperm and eggs.

Rapid and high yield isolation of extracellular vesicles with purity by application of size exclusion fast performance liquid chromatography.

This paper introduces a rapid and high-yield method for isolating extracellular vesicles with high purity, demonstrating its effectiveness across multiple sources and applications.

Evolution of the mutation spectrum across a mammalian phylogeny

The paper quantifies mutation spectrum variation across mammalian species and finds that genetic divergence, not life history traits, best explains mutation spectrum divergence.

Evolution of the SARS-CoV-2 mutational spectrum

This study analyzes changes in the mutation spectrum of SARS-CoV-2 across millions of sequences, finding shifts in mutation rates, particularly a decrease in G[->]T mutations in Omicron compared to early clades.

Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

This study shows that incorporating within-host genetic diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks.

Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice

The paper quantifies phosphonate drugs using 1H-31P HSQC NMR, showing rats provide better drug exposure models than mice for phosphonate-containing compounds.

The apportionment of citations: A scientometric analysis of Lewontin, 1972

This paper analyzes the citation trajectory of Lewontin's 1972 study on human genetic diversity, identifying factors contributing to its enduring influence and examining its role in contemporary discussions about race and genetics.

Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates

The paper evaluates variation in germline mutation rate estimates across labs using a standardized pedigree of rhesus macaques, highlighting methodological differences and the need for standardization.

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

The paper uses a modified fluctuation assay to identify natural mutator phenotypes in S. cerevisiae strains, revealing a 10-fold mutation rate range and distinctive mutation spectra in two strains.

Quantifying and contextualizing the impact of bioRxiv preprints through social media audience segmentation

This study analyzes Twitter engagement with bioRxiv preprints to identify audience segments, revealing that most are academic, but some have significant right-wing nationalist engagement.

Selection against archaic hominin DNA in human regulatory regions

The paper examines depletion of archaic hominin DNA in human regulatory regions, finding young Neandertal and Denisovan SNPs are depleted from enhancers, especially pleiotropic ones, suggesting harmful effects on hybrid fitness.

Joint nonparametric coalescent inference of mutation spectrum history and demography

The paper develops a method to jointly infer demographic history and mutation spectrum changes from genetic data, showing improved accuracy in reconstructing population dynamics and mutation patterns.

Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes

The paper compares four RT-PCR mastermixes and three N gene assays for SARS-CoV-2 detection, finding the N2 assay most sensitive and Takara mastermix best at low detection limits.

CD117/c-kit Represents a Prostate Cancer Stem-Like Subpopulation Driving Progression, Migration, and TKI Resistance

This study shows CD117/c-kit expression in prostate cancer cells correlates with poor survival and promotes aggressiveness, migration, and TKI resistance through CSC-like properties.

Serum proteomics expands on high-affinity antibodies in immunized rabbits than deep B-cell repertoire sequencing alone

This study compares serum proteomics and B-cell repertoire sequencing in rabbits immunized with beta-galactosidase, finding proteomics captures more antibody diversity and partially complements sequencing.

Rapid evolution of the human mutation spectrum

The paper reports differences in mutational spectra across species and human populations, identifying a recent mutation rate change in Europeans.