Oxysterols drive inflammation via GPR183 during influenza virus and SARS-CoV-2 infection
C. X. Foo, S. Bartlett, K. Y. Chew, M. D. Ngo, H. Bielefeldt-Ohmann, B. J. Arachchige, B. Matthews, S. Reed, R. Wang, M. J. Sweet, L. Burr, J. E. Sinclair, R. Parry, A. Khromykh, K. R. Short, , K. Ronacher
This study identifies oxysterols and GPR183 as drivers of inflammation in the lung during influenza and SARS-CoV-2 infections, showing that targeting GPR183 reduces inflammation and disease severity.
bioRxiv · Jun 14, 2022Immunology