R. Wang

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism

This study shows that a ketogenic diet enhances the effectiveness of glutamine metabolism inhibitors in pancreatic cancer by increasing tumor reliance on glutamine for energy.

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin

This study identifies the molecular mechanism by which FIGNL1 disassembles RAD51 filaments from DNA and chromatin, revealing its role in genome stability.

Immunological correlates of protection mediated by a whole organism Cryptococcus neoformans vaccine deficient in chitosan

This paper identifies CD4+ T cells and their cytokines IFNγ, TNF, and IL-23 as critical for vaccine-mediated protection against Cryptococcus neoformans, with protection retained after vaccination even with CD4+ T cell depletion.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

An Infusible Extracellular Matrix Biomaterial Improves Survival in a Model of Severe Systemic Inflammation

This study shows that an infusible extracellular matrix biomaterial improves survival in a mouse model of severe systemic inflammation by reducing inflammation and organ failure.

Piximi - An Images to Discovery web tool for bioimages and beyond

Piximi provides a no-programming web tool for biological image analysis using deep learning, enabling rapid insights without installation or coding.

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

This paper identifies triptolide as a compound that enhances the effectiveness of DNMTi by inhibiting DCTPP1, overcoming resistance in cancer cells.

Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes

The paper investigates how neurofilament tail sequence and phosphorylation affect protein brush conformation using reconstituted brushes and theoretical models.

Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines

This paper develops multivalent cryptococcal vaccines using CAF01 adjuvant that protect mice from experimental cryptococcosis by inducing IFNγ and IL-17 responses.

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection

This study identifies MCPyV protein ALTO as a factor that modulates the STING-TBK1 pathway to limit viral replication and maintain persistent infection.

Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

Comparative transcriptomic and lipidomic analysis of fatty acid accumulation in three Camellia oleifera varieties during maturation

This study compares transcriptomic and lipidomic profiles of three Camellia oleifera varieties during seed maturation, linking fatty acid composition to gene expression patterns.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Imaging and quantification of prostate cancer-associated bone by polarization-sensitive optical coherence tomography

This study uses PS-OCT to differentiate bone tissue types in prostate cancer metastases by analyzing collagen organization and quantifying structural features.

Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression

This study shows that PLK1-mediated PDHA1 phosphorylation impairs mitochondrial function and promotes Cr(VI)-induced lung cancer progression by disrupting energy metabolism and apoptosis.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription

This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.

A video-rate hyperspectral camera for monitoring plant health and biodiversity

This paper introduces a video-rate hyperspectral camera for monitoring plant health and biodiversity, demonstrating its utility in chlorophyll detection and ecological studies.

CRISPR-repressed toxin-antitoxin provides population-level immunity against diverse anti-CRISPR elements

The paper identifies a CRISPR-repressed toxin that provides population-level immunity against diverse anti-CRISPR elements by expelling them through abortive infection-like effects.

Exploring information exchange between Thesium chinense and its host Prunella vulgaris through joint transcriptomic and metabolomic analysis

This study identifies 5 transferred metabolites and 668 mobile genes between Thesium chinense and its host Prunella vulgaris, revealing information exchange critical for haustoria formation and parasitism.

YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.