Author

J. E. Wherry

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

A. C. Huang· 1 shared C. K. Garcia· 1 shared D. Mathew· 1 shared H. Decaluwe· 1 shared H. Huang· 1 shared J. Belman· 1 shared J. C. Beltra· 1 shared J. R. Giles· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. C. Huang

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintOct 3, 2022

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

J. C. Beltra, M. S. Abdel-Hakeem, S. Manne…·J. E. Wherry

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

DOI 10.1101/2022.10.03.509766

mousebulk RNA-seq