D. Mathew

Automated Cytometric Gating with Human-Level Performance Using Bivariate Segmentation

This paper introduces UNITO, a deep learning framework for automated cytometric gating that matches human performance and provides interpretable results without requiring manual input.

Breeding and identification of promising Mauritius x Kew pineapple hybrids with high heterosis for fruit and plant traits

The paper evaluates 25 pineapple hybrids between Mauritius and Kew cultivars, identifying six with high heterosis for fruit and plant traits based on performance metrics.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

This study maps transcriptional and epigenetic changes in CD8 T cell differentiation using scRNA-seq and scATAC-seq, revealing shared biological circuits across effector, memory, and exhausted cell fates.

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

The retromer complex regulates C. elegans development and mammalian ciliogenesis

This study shows the retromer complex is essential for C. elegans development and mammalian ciliogenesis, with a role in CP110 removal from the mother centriole.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

The paper identifies broad immune perturbations in severe COVID-19, including innate and adaptive immune cell changes and heterogeneity in B cell responses and antibody production.

Genome-Wide Association Study and Pathway-Level Analysis of Kernel Color in Maize

This study identifies genetic loci associated with maize kernel color through genome-wide association and pathway analysis, highlighting genes involved in carotenoid biosynthesis and retention.