Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo
F. R. Simonetti, H. Zhang, G. P. Soroosh, J. Duan, K. Rhodehouse, A. L. Hill, S. A. Beg, K. McCormick, H. Raymond, C. L. Nobles, J. Everett, K. J. Kwon, J. A. White, J. Lai, J. B. Margolick, , R. F. Siliciano
This study links antigen responsiveness, proviral sequences, integration sites, and TCRβ sequences to show antigen-driven clonal selection maintains HIV-1 persistence in CD4+ T cells.
bioRxiv · Dec 1, 2020Microbiology