Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable Interaction with CTBP2
D. Pastoors, M. Havermans, R. Mulet-Lazaro, D. Brian, W. Noort, J. Grasel, R. Hoogenboezem, L. Smeenk, J. A. Demmers, T. Enver, R. W. Groen, E. Bindels, R. Delwel
This study identifies EVI1's interaction with CTBP1/CTBP2 as critical for AML and shows that inhibiting this interaction can block leukemic growth.
bioRxiv · Jul 11, 2023Cancer Biology