Author

E. Bindels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:zebrafish· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

R. Hoogenboezem· 4 shared E. de Pater· 3 shared C. Koyunlar· 2 shared D. Bosch· 2 shared E. Gioacchino· 2 shared H. de Looper· 2 shared I. P. Touw· 2 shared J. Zink· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCancer Biology

R. Hoogenboezem

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease

J. D. Windster, L. E. Kuil, N. J. M. Kakiailatu, A. Antanaviciute, A. Sacchetti, K. C. MacKenzie, J. Peulen-Zink, T. W. Kan, E. Bindels, E. de Pater, M. Doukas, S. Yousefi, T. S. Barakat, C. J. H. M. Meeussen, P. C. E. J. Sloots, , M. Alves

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

bioRxiv · Sep 26, 2023Pathology

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable Interaction with CTBP2

D. Pastoors, M. Havermans, R. Mulet-Lazaro, D. Brian, W. Noort, J. Grasel, R. Hoogenboezem, L. Smeenk, J. A. Demmers, T. Enver, R. W. Groen, E. Bindels, R. Delwel

This study identifies EVI1's interaction with CTBP1/CTBP2 as critical for AML and shows that inhibiting this interaction can block leukemic growth.

bioRxiv · Jul 11, 2023Cancer Biology

Deconvolution Of Hematopoietic Stem/Progenitor Cell Signaling Predicts Inflammatory Niche Remodeling To Be A Determinant Of Tissue Failure And Outcome In Human AML

L. Chen, E. Pronk, C. van Dijk, Y. Bian, J. Feyen, T. van Tienhoven, M. Yildirim, P. Pisterzi, M. de Jong, A. Bastidas, R. Hoogenboezem, C. Wevers, E. Bindels, B. Lowenberg, T. Cupedo, , M. Raaijmakers

The paper uses scRNA-seq to analyze signaling between hematopoietic stem/progenitor cells and their niches in AML, identifying inflammatory niche remodeling as a factor affecting tissue failure and patient outcome.

bioRxiv · May 5, 2023 · PreprintCancer Biology

GATA2 haploinsufficiency causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia

E. Gioacchino, W. Zhang, C. Koyunlar, J. Zink, H. de Looper, K. J. Gussinklo, R. Hoogenboezem, D. Bosch, E. Bindels, I. P. Touw, E. de Pater

This study shows that GATA2 haploinsufficiency in zebrafish leads to epigenetic feedback increasing Gata2b expression, causing myeloid and erythroid dysplasia through lineage differentiation defects.

bioRxiv · Oct 29, 2021 · PreprintCancer Biology

Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish

E. Gioacchino, C. Koyunlar, H. de Looper, M. de Jong, T. Dobrzycki, R. Hoogenboezem, J. Zink, D. Bosch, P. van Strien, M. E. van Royen, P. French, E. Bindels, R. Monteiro, K. J. Gussinklo, I. P. Touw, E. de Pater

This study identifies Gata2b's role in myeloid-lymphoid lineage decisions in zebrafish using single-cell transcriptomics.

bioRxiv · Sep 4, 2019 · PreprintImmunology