RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signalling
K. Chen, B. Demarco, R. Heilig, S. Ramos, J. Grayczyk, C.-A. Assenmacher, E. Radaelli, L. Joannas, J. Henao-Mejia, I. Brodsky, P. Broz
The paper shows that RIPK1 activates GSDME in neutrophils to promote anti-Yersinia defence through pyroptosis and IL-1β release.
bioRxiv · Jan 20, 2021Immunology