Author

B. Demarco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Broz· 3 shared J. Henao-Mejia· 2 shared L. Joannas· 2 shared A. A. DeLaney· 1 shared B. C. Schaefer· 1 shared B. L. Lee· 1 shared C.-A. Assenmacher· 1 shared D. Grubaugh· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

P. Broz

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Author profile →

3 papers

Recent·Most cited

Gasdermin D is the only Gasdermin that provides non-redundant protection against acute Salmonella gut infection

S. A. Fattinger, L. Maurer, P. Geiser, U. Enz, S. Ganguillet, E. Gul, S. Kroon, B. Demarco, M. Furter, M. Barthel, P. Pelczar, F. Shao, P. Broz, M. E. Sellin, W.-D. Hardt

This study identifies Gasdermin D as the only Gasdermin providing non-redundant protection against acute Salmonella Typhimurium gut infection by restricting bacterial loads, controlling inflammation, and preventing epithelial disruption.

bioRxiv · Nov 24, 2022Immunology

Genetic targeting of Card19 is linked to disrupted Ninj1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

E. Bjanes, R. G. Sillas, R. Matsuda, B. Demarco, T. Fettrelet, A. A. DeLaney, O. S. Kornfeld, B. L. Lee, E. M. Rodriguez Lopez, D. Grubaugh, M. A. Wynosky-Dolfi, N. H. Philip, E. Krespan, D. Tovar, L. Joannas, , I. E. Brodsky

This study shows that genetic targeting of Card19 disrupts Ninj1 expression, impairs macrophage cell lysis, and increases susceptibility to Yersinia infection.

bioRxiv · Mar 19, 2021 · PreprintImmunology

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signalling

K. Chen, B. Demarco, R. Heilig, S. Ramos, J. Grayczyk, C.-A. Assenmacher, E. Radaelli, L. Joannas, J. Henao-Mejia, I. Brodsky, P. Broz

The paper shows that RIPK1 activates GSDME in neutrophils to promote anti-Yersinia defence through pyroptosis and IL-1β release.

bioRxiv · Jan 20, 2021Immunology