Author

J. Harkonen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A.-L. Levonen· 2 shared I. Selvarajan· 2 shared M. U. Kaikkonen· 2 shared A. J. Deen· 1 shared A. Jawahar-Deen· 1 shared A. Poso· 1 shared E. Dimova· 1 shared E. Kansanen· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

A.-L. Levonen

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2 papers

Recent·Most cited

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

A. J. Deen, S. Adinolfi, J. Harkonen, T. Patinen, X. Liu, T. Laitinen, P. Takabe, K. Kainulainen, S. Pasonen-Seppanen, L. Gawriyski, U. Thanigai Arasu, I. Selvarajan, P. Makinen, H. Laitinen, E. Kansanen, , A.-L. Levonen

This study shows that KEAP1 mutations in lung cancer activate TRAF2-NFκB signaling, enhancing cell survival by preventing apoptosis.

bioRxiv · Oct 10, 2023Cancer Biology

Pan-cancer scale screening reveals NRF2 associated immunoevasive characteristics in non-small cell lung cancer and squamous malignancies

J. Harkonen, P. Polonen, A. Jawahar-Deen, I. Selvarajan, H.-R. Teppo, E. Dimova, T. Kietzmann, M. Ahtiainen, T. Eklund, T. Kuopio, E.-M. Talvitie, P. Taimen, M. Kallajoki, M. U. Kaikkonen, M. Heinaniemi, A.-L. Levonen

This paper identifies NRF2-associated immunoevasive features in NSCLC and squamous cancers, linking NRF2 activity to immune-cold phenotypes and potential biomarkers for immune checkpoint response.

bioRxiv · May 15, 2022 · PreprintCancer Biology