J. Hawkey

Genomic dissection of endemic carbapenem resistance: metallo-beta-lactamase gene dissemination through clonal, plasmid and integron transfer pathways

The paper tracks the evolution and spread of the blaIMP-4 gene across multiple bacterial strains and plasmids in a hospital setting over two decades.

Within-patient and global evolutionary dynamics of Klebsiella pneumoniae ST17

This study investigates the within-host evolution and global spread of Klebsiella pneumoniae ST17, finding limited within-host genetic change and identifying its role in multidrug-resistant hospital infections.

Transmission of Klebsiella strains and plasmids within and between Grey-headed flying fox colonies

This study identifies transmission clusters and plasmid exchange among Klebsiella strains in Grey-headed flying foxes, showing gene flow between bat and human-associated isolates.

Linear plasmids in Klebsiella and other Enterobacteriaceae

This study identifies and characterizes linear plasmids in Klebsiella pneumoniae and other Enterobacteriaceae, revealing their phylogenetic diversity and potential for horizontal transfer.

A curated collection of Klebsiella metabolic models reveals variable substrate usage and gene essentiality

The paper curates 37 strain-specific genome-scale metabolic models for Klebsiella pneumoniae species complex isolates, revealing strain-specific metabolic differences and gene essentiality.

Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei

The paper develops a genomic framework and genotyping scheme for Shigella sonnei to identify resistance determinants from WGS data, revealing common genotypes linked to antimicrobial resistance and global spread.

Impact of insertion sequences on convergent evolution of Shigella species

This study examines the role of insertion sequences in the convergent evolution of Shigella species, showing their contribution to gene loss and metabolic streamlining across species.

Global phylogenomics of multidrug resistant Salmonella enterica serotype Kentucky ST198

This study uses whole-genome sequencing to analyze the global spread and antimicrobial resistance of Salmonella enterica serotype Kentucky ST198, identifying a single clonal lineage responsible for multidrug resistance.

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

The paper tracks the emergence and global spread of a CTX-M-15-producing K. pneumoniae strain ST307, showing it originated in the mid-1990s and is associated with a plasmid containing antimicrobial resistance genes.